Faecal microbiota transplantation (FMT) has a role in treating recurrent Clostridium difficile infection; however, practical concerns regarding modes of administration have limited its widespread use. Youngster and colleagues investigated the safety and efficacy of frozen FMT capsules (from prescreened unrelated donors) for the treatment of recurrent C. difficile infection in 20 patients. No serious adverse events were noted, and 18 of 20 patients achieved resolution of diarrhoea. Large studies are needed to confirm these results.
References
Youngster, I. et al. Oral, capsulized, frozen fecal microbiota transplantation for relapsing Clostridium difficile infection. JAMA 10.1001/jama.2014.13875
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Treating Clostridium difficile infection: a bitter pill to swallow. Nat Rev Gastroenterol Hepatol 11, 702 (2014). https://doi.org/10.1038/nrgastro.2014.193
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DOI: https://doi.org/10.1038/nrgastro.2014.193