A new 'intelligent knife' provides near-real-time intraoperative tissue analysis and enables accurate differentiation between malignant and benign tissue. This ability to 'smell' cancer could be applicable to a variety of oncological operations in gastroenterology, but some questions and limitations remain as this interesting new technology is explored.
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References
Sawady, J., Berner, J. J. & Siegler, E. E. Accuracy of and reasons for frozen sections: a comprehensive, retrospective study. Hum. Pathol. 19, 1019–1023 (1988).
Chatelain, D. et al. Intraoperative consultation in digestive surgery. J. Visceral Surg. 149, e134–e142 (2012).
Mahe, E. et al. Intraoperative pathology consultation: error, cause and impact. Can. J. Surg. 56, E13–E18 (2013).
Balog, J. et al. Intraoperative tissue identification using rapid evaporative ionization mass spectrometry. Sci. Transl. Med. 5, 194ra93 (2013).
Balog, J. et al. Identification of biological tissues by rapid evaporative ionization mass spectrometry. Anal. Chem. 82, 7343–7350 (2010).
Younes, M. Frozen section of the gastrointestinal tract, appendix, and peritoneum. Arch. Pathol. Lab. Med. 129, 1558–1564 (2005).
Miedema, J. R. & Hunt, H. V. Practical issues for frozen section diagnosis in gastrointestinal and liver diseases. J. Gastrointestin. Liver Dis. 19, 181–185 (2010).
Nelson, H. et al. Guidelines 2000 for colon and rectal cancer surgery. J. Natl Cancer Inst. 93, 583–596 (2001).
Devereux, D. F. & Deckers, P. J. Contributions of pathologic margins and dukes' stage to local recurrence in colorectal carcinoma. Am. J. Surg. 149, 323–326 (1985).
Colibaseanu, D. T. et al. Is curative resection and long-term survival possible for locally re-recurrent colorectal cancer in the pelvis? Dis. Colon Rectum 56, 14–19 (2013).
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Crawshaw, B., Delaney, C. Real-time tissue identification during surgery. Nat Rev Gastroenterol Hepatol 10, 624–625 (2013). https://doi.org/10.1038/nrgastro.2013.176
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DOI: https://doi.org/10.1038/nrgastro.2013.176