Patients with Parkinson disease are frequently treated with levodopa (L-dopa), but L-dopa delays gastric emptying, which lessens its absorption. In fasted rats, Wang et al. have shown that intravenous ghrelin can counteract the inhibition of gastric emptying by L-dopa and increase plasma levels of L-dopa and dopamine. In addition, ghrelin did not modify the induction of Fos in the brain by L-dopa.