Insulin resistance is a predictor of poor response to PEG-IFN-α and ribavirin in patients with chronic HCV infection, but data are lacking for direct-acting antivirals. Serfaty et al. investigated the prognostic significance of insulin resistance in 161 treatment-naive patients infected with HCV genotype 1, who received telaprevir followed by PEG-IFN-α and ribavirin. Insulin resistance was not found to be predictive of virologic response to telaprevir.
ORIGINAL RESEARCH PAPER
Serfaty, L. et al. Insulin resistance and response to telaprevir plus peginterferon α and ribavirin in treatment-naive patients infected with HCV genotype 1. Gut doi:10.1136/gutjnl-2011-300749
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Franks, I. Insulin resistance is not predictive of virologic response to telaprevir. Nat Rev Gastroenterol Hepatol 9, 242 (2012). https://doi.org/10.1038/nrgastro.2012.52
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DOI: https://doi.org/10.1038/nrgastro.2012.52
