MyD88 is a Toll-like receptor adaptor protein that regulates intestinal homeostasis in mammals. Donna Kirkland and colleagues used cell-type-specific Myd88-deficient mice to demonstrate that B-cell-intrinsic MyD88 signaling is key to resistance to colonic damage induced by dextran sulfate sodium. MyD88 is involved in the production of IgM and complement-mediated control of intestinal bacteria. Therefore, mammals that lack functioning MyD88 signaling in B cells quickly die, as commensal bacteria become highly pathogenic in this setting.
ORIGINAL RESEARCH PAPER
Kirkland, D. et al. B cell-intrinsic MyD88 signaling prevents the lethal dissemination of commensal bacteria during colonic damage. Immunity 36, 228–238 (2012)
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Preventing lethal dissemination of commensal bacteria. Nat Rev Gastroenterol Hepatol 9, 189 (2012). https://doi.org/10.1038/nrgastro.2012.37
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DOI: https://doi.org/10.1038/nrgastro.2012.37