Infection with the human pathogen Salmonella Typhi has been modelled in mice—normally resistant to S. Typhi infection. Toll-like receptor 11 (TLR11), expressed in mice but not humans, recognizes bacterial flagellin and triggers a protective immune response. In this study, tlr11−/− mice were found to be susceptible to infection following oral delivery of S. Typhi; these mice could also be successfully immunized. The tlr11−/− model might provide new insights into the immune response to S. Typhi and promote vaccine development.
ORIGINAL RESEARCH PAPER
Mathur, R. et al. A mouse model of Salmonella Typhi infection. Cell 151, 590–602 (2012)
Rights and permissions
About this article
Cite this article
Modelling Salmonella Typhi infection in mice. Nat Rev Gastroenterol Hepatol 9, 688 (2012). https://doi.org/10.1038/nrgastro.2012.216
Published:
Issue Date:
DOI: https://doi.org/10.1038/nrgastro.2012.216