Wu et al. identified nine new oesophageal squamous cell carcinoma susceptibility loci in their genome-wide association study (2,031 cases and 2,044 controls, with validation in 8,092 cases and 8,620 controls). Seven loci had a significant but marginal effect; risk associated with variants at the 4q23 locus also had a significant interaction with alcohol use. Two loci (at 2q22 and 13q33) had a significant association only in a gene–alcohol drinking interaction.
ORIGINAL RESEARCH PAPER
Wu, C. et al. Genome-wide association analyses of esophageal squamous cell carcinoma in Chinese identify multiple susceptibility loci and gene–environment interactions. Nat. Genet. doi:10.1038/ng.2411
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Genetic contribution to risk of oesophageal squamous cell carcinoma and interaction with alcohol use confirmed. Nat Rev Gastroenterol Hepatol 9, 616 (2012). https://doi.org/10.1038/nrgastro.2012.190
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DOI: https://doi.org/10.1038/nrgastro.2012.190
