Variants at two loci are associated with risk of Barrett oesophagus, as shown by a genome-wide association study (1,852 cases and 5,172 controls, with replication in 5,986 cases and 12,825 controls). 6p21 is within the MHC locus; FOXF1, the nearest protein-coding gene to 16q24, is thought to have a role in oesophageal development and structure. The authors also say that SNP alleles predisposing to obesity increase the risk of Barrett oesophagus.
ORIGINAL RESEARCH PAPER
The Esophageal Adenocarcinoma Genetics Consortium et al. Common variants at the MHC locus and at chromosome 16q24.1 predispose to Barrett's esophagus. Nat. Genet. doi:10.1038/ng.2408
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Genome-wide association study uncovers contributors to genetic susceptibility to Barrett oesophagus. Nat Rev Gastroenterol Hepatol 9, 616 (2012). https://doi.org/10.1038/nrgastro.2012.189
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DOI: https://doi.org/10.1038/nrgastro.2012.189
