A new technique has been developed that enables real-time monitoring of bile acid transport in single living cells. A genetically encoded fluorescent sensor enables visualization of uptake and accumulation of conjugated bile acids. This technique could increase understanding of the role bile acids have in metabolism and absorption of dietary lipids and vitamins.
ORIGINAL RESEARCH PAPER
van der Velden, L. M. et al. Monitoring bile acid transport in single living cells using a genetically encoded FRET sensor. Hepatology doi:10.1002/hep.26012
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Imaging bile acid transport in single living cells. Nat Rev Gastroenterol Hepatol 9, 558 (2012). https://doi.org/10.1038/nrgastro.2012.179
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DOI: https://doi.org/10.1038/nrgastro.2012.179