Patients with IBS have visceral hypersensitivity. Serotonergic modulation can alter visceral perception and be of benefit in some patients with IBS; however, it is unclear whether serotonergic modulation alters rectal motor function in these patients. In a randomized, double-blind, placebo-controlled, crossover study, acute tryptophan depletion and citalopram (a selective serotonin reuptake inhibitor) did not affect rectal motor function in healthy control individuals or patients with diaorrhea-predominant IBS.
ORIGINAL RESEARCH PAPER
van Nieuwenhoven, M. A. & Kilkens, T. O. C. The effect of acute serotonergic modulation on rectal motor function in diarrhea-predominant irritable bowel syndrome and healthy controls. Eur. J. Gastroenterol. Hepatol. doi:10.1097/MEG.0b013e3283583cf5
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Rectal motor function in patients with IBS. Nat Rev Gastroenterol Hepatol 9, 558 (2012). https://doi.org/10.1038/nrgastro.2012.177
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DOI: https://doi.org/10.1038/nrgastro.2012.177