A combined analysis of genome-wide association studies for primary sclerosing cholangitis (PSC) and ulcerative colitis has uncovered two new PSC risk loci with genome-wide significance—GPR35 and TCF4. While TCF4 is a risk loci for PSC alone, GPR35 is a risk loci for both PSC and ulcerative colitis. The authors say “Both loci may represent previously unexplored aspects of PSC pathogenesis.”
ORIGINAL RESEARCH PAPER
Ellinghaus, D. et al. Genome-wide association analysis in sclerosing cholangitis and ulcerative colitis identifies risk loci at GPR35 and TCF4. Hepatology doi:10.1002/hep.25977
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Two new primary sclerosing cholangitis risk loci identified. Nat Rev Gastroenterol Hepatol 9, 488 (2012). https://doi.org/10.1038/nrgastro.2012.148
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DOI: https://doi.org/10.1038/nrgastro.2012.148
