A study by Lebrec and colleagues suggests that, despite having no effect on short-term mortality, pentoxifylline, an inhibitor of tumor necrosis factor, reduces the risk of liver-related complications in patients with advanced Child–Turcotte–Pugh class C cirrhosis.
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References
Lebrec, D. et al. Pentoxifylline does not decrease short-term mortality but does reduce complications in patients with advanced cirrhosis. Gastroenterology 138, 1755–1762 (2010).
Bird, G. L., Sheron, N., Goka, A. K., Alexander, G. J. & Williams, R. S. Increased plasma tumor necrosis factor in severe alcoholic hepatitis. Ann. Intern. Med. 112, 917–920 (1990).
Goulis, J., Patch, D. & Burroughs, A. K. Bacterial infection in the pathogenesis of variceal bleeding. Lancet 353, 139–142 (1999).
Katakami, Y. et al. Regulation of tumour necrosis factor production by mouse peritoneal macrophages: the role of cellular cyclic AMP. Immunology 64, 719–724 (1988).
Strieter, R. M. et al. Cellular and molecular regulation of tumor necrosis factor-alpha production by pentoxifylline. Biochem. Biophys. Res. Commun. 155, 1230–1236 (1988).
Soupison, T. et al. Acute haemodynamic responses and inhibition of tumour necrosis factor-alpha by pentoxifylline in rats with cirrhosis. Clin. Sci. (Lond.) 91, 29–33 (1996).
Akriviadis, E. et al. Pentoxifylline improves short-term survival in severe acute alcoholic hepatitis: A double-blind, placebo-controlled trial. Gastroenterology 119, 1637–1648 (2000).
Schade, U. F. Pentoxifylline increases survival in murine endotoxin shock and decreases formation of tumor necrosis factor. Circ. Shock 31, 171–181 (1990).
Diehl, A. M. & Rai, R. Review: regulation of liver regeneration by pro-inflammatory cytokines. J. Gastroenterol. Hepatol. 11, 466–470 (1996).
Boetticher, N. C. et al. A randomized, double-blinded, placebo-controlled multicenter trial of etanercept in the treatment of alcoholic hepatitis. Gastroenterology 135, 1953–1960 (2008).
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Kendrick, S., Day, C. Can pentoxifylline secure its place in liver therapeutics?. Nat Rev Gastroenterol Hepatol 7, 593–594 (2010). https://doi.org/10.1038/nrgastro.2010.150
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DOI: https://doi.org/10.1038/nrgastro.2010.150