A meta-analysis of 15 genome-wide association studies of inflammatory bowel disease (IBD) has been carried out and analysed along with data from an Immunochip study. One hundred and sixty-three loci were identified — the most for any complex disease to date. Many IBD loci were implicated in other immune-related disorders, and there was an overlap between IBD and mycobacterial infection susceptibility loci. Evidence for directional and balancing selection at IBD loci was also uncovered.
ORIGINAL RESEARCH PAPER
Jostins, L. et al. Host–microbe interactions have shaped the genetic architecture of inflammatory bowel disease. Nature 491, 119–124 (2012)
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Stower, H. Inflammatory bowel disease genetic association. Nat Rev Genet 13, 826 (2012). https://doi.org/10.1038/nrg3379
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DOI: https://doi.org/10.1038/nrg3379