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Transplantation

Sustained benefits of islet transplants for T1DM

Nature Reviews Endocrinology volume 11, pages 572–574 (2015)Cite this article

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In a retrospective multicentre study of patients with type 1 diabetes mellitus, islet transplantation was associated with sustained HbA1c levels of <7% and freedom from severe hypoglycaemia for 5 years in 60% of immunosuppressed recipients, including those with recurrent severe pretransplant hypoglycaemia. Will islet transplant utilization in patient care now expand?

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Acknowledgements

The authors would like to acknowledge that their work on human islet transplantation in type 1 diabetes mellitus has been supported in part by a USA Public Health Service research grant (UO1-AI065193) awarded by the NIH.

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Authors and Affiliations

  1. Schulze Diabetes Institute, University of Minnesota, MMC 195, 420 Delaware Street S.E., Minneapolis, 55455, MN, USA

    Bernhard J. Hering & Melena D. Bellin

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  1. Bernhard J. Hering
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  2. Melena D. Bellin
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Correspondence to Bernhard J. Hering.

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Competing interests

B.J.H. is a consultant for Janssen Research and Development and is a Director of Diabetes-Free, Inc. M.D.B. has received research support from Dompe, Medtronic and Merck, and is a consultant for Viacyte.

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Hering, B., Bellin, M. Sustained benefits of islet transplants for T1DM. Nat Rev Endocrinol 11, 572–574 (2015). https://doi.org/10.1038/nrendo.2015.126

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