Using metabolomics, Wang et al. have identified 2-aminoadipic acid (2-AAA) as a new metabolite biomarker of diabetes risk. This nested case–control study included 188 individuals who developed diabetes mellitus and 188 propensity-matched controls selected from 2,422 normoglycaemic participants followed up for 12 years in the Framingham Heart Study. The investigators found that individuals with 2-AAA concentrations in the top quartile had a greater than fourfold risk of developing diabetes mellitus. Levels of the metabolite were increased up to 12 years before the onset of overt disease.
References
Wang, T. J. et al. 2-Aminoadipic acid is a biomarker for diabetes risk. J. Clin. Invest. 10.1172/JCI64801
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Novel predictor of diabetes development identified. Nat Rev Endocrinol 9, 692 (2013). https://doi.org/10.1038/nrendo.2013.196
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DOI: https://doi.org/10.1038/nrendo.2013.196