Beige adipose tissue is anabolic for bone, show Rahman and colleagues. Using mouse models and in vitro experiments, the researchers demonstrate that beige adipose tissue secretes factors, including IGFBP-2 and Wnt-10b, that target two types of bone cells for anabolic activity: osteoblasts and osteocytes. They suggest that beige adipose tissue could be targeted for the treatment of both metabolic and bone diseases.
ORIGINAL RESEARCH PAPER
Rahman, S. et al. Inducible brown adipose tissue, or beige fat, is anabolic for the skeleton. Endocrinology doi:10.1210/en.2012-2162
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Beige adipose tissue is beneficial for the skeleton. Nat Rev Endocrinol 9, 442 (2013). https://doi.org/10.1038/nrendo.2013.118
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DOI: https://doi.org/10.1038/nrendo.2013.118
