Tudhope and colleagues tested the effects of serotonin (5-hydroxytryptamine [5-HT]) on postprandial hepatic glucose uptake. They found that 5-HT had both stimulatory and inhibitory effects on glycogen synthesis in hepatocytes, which were mediated by 5-HT1F/5-HT2A and 5-HT2B receptors, respectively. These opposing effects could underlie the hyperglycemia or hypoglycemia caused by drugs targeting serotonin function, suggest the investigators.
ORIGINAL RESEARCH PAPER
Tudhope, S. J. et al. A novel mechanism for regulating hepatic glycogen synthesis involving serotonin and cyclin-dependent kinase-5. Diabetes doi:10.2337/db11-0870
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Regulation of hepatic glycogenesis by serotonin. Nat Rev Endocrinol 8, 68 (2012). https://doi.org/10.1038/nrendo.2011.219
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DOI: https://doi.org/10.1038/nrendo.2011.219
