Thyroid nodules are frequent clinical findings, but only a small proportion is malignant. Differential diagnosis and risk stratification for thyroid malignancy is, therefore, required to avoid unnecessary surgery. Could immunostaining of two protein markers ramp up a clinician's ability to distinguish lesions that require surgical intervention from those that do not?
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References
Fadda, G. et al. Follicular thyroid neoplasms can be classified as low- and high-risk according to HBME-1 and galectin-3 expression on liquid-based fine-needle cytology. Eur. J. Endocrinol. 165, 447–453 (2011).
British Thyroid Association and Royal College of Physicians. Guidelines for the management of thyroid cancer, 2nd edn [online]. (2007).
American Thyroid Association (ATA) Guidelines Taskforce on Thyroid Nodules and Differentiated Thyroid Cancer et al. Revised American Thyroid Association management guidelines for patients with thyroid nodules and differentiated thyroid cancer. Thyroid 19, 1167–1214 (2009).
Gharib, H. et al. American Association of Clinical Endocrinologists, Associazione Medici Endocrinologi, and European Thyroid Association medical guidelines for clinical practice for the diagnosis and management of thyroid nodules: executive summary of recommendations. J. Endocrinol. Invest. 33 (Suppl. 5), 51–56 (2010).
Hegedus, L. Clinical practice. The thyroid nodule. N. Engl. J. Med. 351, 1764–1771 (2004).
Griffith, O. L., Chiu, C. G., Gown, A. M., Jones, S. J. & Wiseman, S. M. Biomarker panel diagnosis of thyroid cancer: a critical review. Expert Rev. Anticancer Ther. 8, 1399–1413 (2008).
Cheung, C. C., Ezzat, S., Freeman, J. L., Rosen, I. B. & Asa, S. L. Immunohistochemical diagnosis of papillary thyroid carcinoma. Mod. Pathol. 14, 338–342 (2001).
Cheng, S., Serra, S., Mercado, M., Ezzat, S. & Asa, S. L. A high-throughput proteomic approach provides distinct signatures for thyroid cancer behavior. Clin. Cancer Res. 17, 2385–2394 (2011).
Nikiforov, Y. E. et al. Molecular testing for mutations in improving the fine-needle aspiration diagnosis of thyroid nodules. J. Clin. Endocrinol. Metab. 94, 2092–2098 (2009).
Ohori, N. P. et al. Contribution of molecular testing to thyroid fine-needle aspiration cytology of “follicular lesion of undetermined significance/atypia of undetermined significance”. Cancer Cytopathol. 118, 17–23 (2010).
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Boelaert, K., McCabe, C. Finding the malignant thyroid nodule in the haystack. Nat Rev Endocrinol 7, 563–564 (2011). https://doi.org/10.1038/nrendo.2011.152
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DOI: https://doi.org/10.1038/nrendo.2011.152
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