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Diabetes

Brain, mind, insulin—what is normal and do we need to know?

Diabetes mellitus has been linked to brain abnormalities and cognitive decline. A report from the Framingham Offspring Study now demonstrates that, in middle-aged and older adults, the core metabolic indicators of diabetes mellitus correlate with continuously distributed properties of brain and cognition, within a clinically normal range.

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References

  1. Raz, N. & Rodrigue, K. M. Differential aging of the brain: patterns, cognitive correlates and modifiers. Neurosci. Biobehav. Rev. 30, 730–748 (2006).

    Article  Google Scholar 

  2. Tan, Z. S. et al. Association of metabolic dysregulation with volumetric brain magnetic resonance imaging and cognitive markers of subclinical brain aging in middle-aged adults: The Framingham offspring study. Diabetes Care 34, 1766–1770 (2011).

    Article  Google Scholar 

  3. den Heijer, T. et al. Type 2 diabetes and atrophy of medial temporal lobe structures on brain MRI. Diabetologia 46, 1604–1610 (2003).

    Article  CAS  Google Scholar 

  4. Kuusisto, J. et al. Essential hypertension and cognitive function. The role of hyperinsulinemia. Hypertension 22, 771–779 (1993).

    Article  CAS  Google Scholar 

  5. Convit, A., Wolf, O. T., Tarshish, C. & de Leon, M. J. Reduced glucose tolerance is associated with poor memory performance and hippocampal atrophy among normal elderly. Proc. Natl Acad. Sci. USA 100, 2019–2022 (2003).

    Article  CAS  Google Scholar 

  6. Dahle, C. L., Jacobs, B. S. & Raz, N. Aging, vascular risk and cognition: Blood glucose, pulse pressure, and cognitive performance in healthy adults. Psychol. Aging 24, 154–162 (2009).

    Article  Google Scholar 

  7. Raz, N. et al. Brain-derived neurotrophic factor Val66Met and blood glucose: a synergistic effect on memory. Front. Hum. Neurosci. 2, 12 (2008).

    Article  Google Scholar 

  8. Maxwell, S. E. & Cole, D. A. Bias in cross-sectional analyses of longitudinal mediation. Psychol. Methods 12, 23–44 (2007).

    Article  Google Scholar 

  9. Zade, D. et al. Interactive effects of apolipoprotein E type 4 genotype and cerebrovascular risk on neuropsychological performance and structural brain changes. J. Stroke Cerebrovasc. Dis. 19, 261–268 (2010).

    Article  Google Scholar 

  10. Raz, N. & Kennedy, K .M. in Imaging the Aging Brain 1st edn Ch. 4 (eds Jagust, W. & D'Esposito, M.) 43–70 (Oxford University Press, New York, 2009).

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Raz, N. Brain, mind, insulin—what is normal and do we need to know?. Nat Rev Endocrinol 7, 636–637 (2011). https://doi.org/10.1038/nrendo.2011.149

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