Sphingosine-1-phosphate (S1P) is a bioactive lipid that has a key role in the control of immune cell trafficking. In their Review on p688, Spiegel and colleagues discuss how the S1P axis could be targeted in disorders including cancer and inflammation.
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Harrison, C. Recent patents related to S1P. Nat Rev Drug Discov 12, 657 (2013). https://doi.org/10.1038/nrd4125
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DOI: https://doi.org/10.1038/nrd4125