A study of >200 cholangiocarcinomas has revealed marked differences in the mutational patterns between cancers caused by Opisthorchis viverrini infection and those without infectious aetiologies. Namely, BAP1, IDH1 and IDH2 mutations were more common in noninfectious cancers, whereas TP53 mutations were common within the O. viverrini-related cancers. These results show how certain environmental exposures can dramatically change the somatic mutational landscape of this common hepatic cancer.
References
Chan-on, W. et al. Exome sequencing identifies distinct mutational patterns in liver fluke-related and non-infection-related bile duct cancers. Nat. Genet. 10.1038/ng.2806
Rights and permissions
About this article
Cite this article
Aetiology might dictate mutation in biliary duct cancer. Nat Rev Clin Oncol 11, 2 (2014). https://doi.org/10.1038/nrclinonc.2013.224
Published:
Issue Date:
DOI: https://doi.org/10.1038/nrclinonc.2013.224