Seven low-frequency single-nucleotide polymorphisms (SNPs) at 8q24.21, identified using techniques such as long-range PCR, have been associated with the risk of developing various gliomas. In the 1,657 case and 1,301 control samples examined, the SNP rs55705857 was significantly correlated with the development of oligodendroglial tumours and gliomas with IDH1 or IDH2 mutations. Astrocytomas without IDH mutations were not significantly associated with rs55705857, which suggests that the risk locus in 8q24 interacts with IDH mutations in the development and progression of gliomas.
ORIGINAL RESEARCH PAPER
Jenkins, R. B. et al. A low-frequency variant at 8q24.21 is strongly associated with risk of oligodendrogial tumors and astrocytomas with IDH1 or IDH2 mutation. Nat. Genet. doi:10.1038/ng.2388
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SNP genotyping reveals correlation with glioma development. Nat Rev Clin Oncol 9, 608 (2012). https://doi.org/10.1038/nrclinonc.2012.168
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DOI: https://doi.org/10.1038/nrclinonc.2012.168