Suboptimal studies had established preoperative chemoradiation as the preferred strategy in the management of localized oesophageal cancer (LEC) and gastro-oesophageal cancer. The recent CROSS trial has now demonstrated considerable benefit from preoperative chemoradiation over surgery alone in patients with LEC. But, are these results only reinforcing advocates of the preoperative chemoradiation strategy?
Key Points
The CROSS study, which provided excellent evidence in support for preoperative chemoradiation therapy of patients with localized gastro-oesophageal junction cancer, establishes a platform we can build on.
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References
Hampel, H., Abraham, N. S. & El-Serag, H. B. Meta-analysis: obesity and the risk for gastroesophageal reflux disease and its complications. Ann. Intern. Med. 143, 199–211 (2005).
Brown, L. M., Devesa, S. S. & Chow, W. H. Incidence of adenocarcinoma of the esophagus among white Americans by sex, stage, and age. J. Natl Cancer Inst. 100, 1184–1187 (2008).
Brown, L. M. et al. Adenocarcinoma of the esophagus: role of obesity and diet. J. Natl Cancer Inst. 87, 104–109 (1995).
Answers™. Esophageal cancer [online] (2012).
Rice, T. W. et al. Worldwide esophageal cancer collaboration. Dis. Esophagus 22, 1–8 (2009).
Birkmeyer, J. D., Sun, Y., Wong, S. L. & Stukel, T. A. Hospital volume and late survival after cancer surgery. Ann. Surg. 245, 777–783 (2007).
Kelsen, D. P. et al. Chemotherapy followed by surgery compared with surgery alone for localized esophageal cancer. N. Engl. J. Med. 339, 1979–1984 (1998).
Allum, W. H., Stenning, S. P., Bancewicz, J., Clark, P. I. & Langley, R. E. Long-term results of a randomized trial of surgery with or without preoperative chemotherapy in esophageal cancer. J. Clin. Oncol. 27, 5062–5067 (2009).
van Hagen, P. et al. Preoperative chemoradiotherapy for esophageal or junctional cancer. N. Engl. J. Med. 366, 2074–2084 (2012).
Viklund, P. et al. Risk factors for complications after esophageal cancer resection: a prospective population-based study in Sweden. Ann. Surg. 243, 204–211 (2006).
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Blum, M., Ajani, J. Gastro-oesophageal cancer—is CROSSing over so hard to do?. Nat Rev Clin Oncol 9, 493–494 (2012). https://doi.org/10.1038/nrclinonc.2012.122
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DOI: https://doi.org/10.1038/nrclinonc.2012.122
