CONFIRM Registry researchers have published findings from a study of 10,037 symptomatic patients who underwent coronary artery calcification (CAC) scoring and coronary CT angiography (CCTA) to assess extent of coronary artery disease. For CCTA-determined stenosis ≥50%, a CAC score >0 had sensitivity of 89%, specificity of 59%, and negative and positive predictive values of 96% and 29%, respectively. Receiver–operator characteristic curve analysis showed CAC score added no incremental prognostic information to CCTA assessment of coronary artery disease for the composite end point of mortality, myocardial infarction, or late coronary revascularization (areas under the curve for CCTA alone and CCTA plus CAC score were 0.825 and 0.826, respectively; P = 0.84).
ORIGINAL RESEARCH PAPER
Villines, T. C. et al. Prevalence and severity of coronary artery disease and adverse events among symptomatic patients with coronary artery calcification scores of zero undergoing coronary computed tomography angiography: results from the CONFIRM (Coronary CT Angiography Evaluation for Clinical Outcomes: An International Multicenter) Registry. J. Am. Coll. Cardiol. doi:10.1016/j.jacc.2011.10.851
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CAC score adds no incremental prognostic information to CCTA for cardiovascular events in symptomatic patients. Nat Rev Cardiol 9, 6 (2012). https://doi.org/10.1038/nrcardio.2011.191
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DOI: https://doi.org/10.1038/nrcardio.2011.191
