Two studies in this issue show that the protein MeCP2, which is implicated in Rett syndrome, also critically regulates behavioral responses to psychostimulants. Although the two studies highlight different mechanisms of MeCP2 in regulating these behaviors, both underscore the importance of epigenetic mechanisms in establishing drug addiction.
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Feng, J., Nestler, E. MeCP2 and drug addiction. Nat Neurosci 13, 1039–1041 (2010). https://doi.org/10.1038/nn0910-1039
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DOI: https://doi.org/10.1038/nn0910-1039
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