Previous experiments have suggested that many P2X family channels undergo a time-dependent process of pore dilation when activated by ATP. Li et al. now propose a different interpretation of the key experiments.
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Hille, B. Ion Channels of Excitable Membranes (Sinauer, Sunderland, Massachusetts, 2001).
Virginio, C., MacKenzie, A., Rassendren, F.A., North, R.A. & Surprenant, A. Nat. Neurosci. 2, 315–321 (1999).
Khakh, B.S., Bao, X.R., Labarca, C. & Lester, H.A. Nat. Neurosci. 2, 322–330 (1999).
Yan, Z., Li, S., Liang, Z., Tomic, M. & Stojilkovic, S.S. J. Gen. Physiol. 132, 563–573 (2008).
Chung, M.K., Guler, A.D. & Caterina, M.J. Nat. Neurosci. 11, 555–564 (2008).
Banke, T.G., Chaplan, S.R. & Wickenden, A.D. Am. J. Physiol. Cell Physiol. 298, C1457–C1468 (2010).
Li, M., Toombes, G.E.S., Silberberg, S.D. & Swartz, K.J. Nat. Neurosci. 18, 1577–1583 (2015).
Frankenhaeuser, B. & Hodgkin, A.L. J. Physiol. (Lond.) 131, 341–376 (1956).
Frazier, C.J., George, E.G. & Jones, S.W. Biophys. J. 78, 1872–1880 (2000).
Puopolo, M. et al. J. Neurophysiol. 109, 1704–1712 (2013).
Browne, L.E., Compan, V., Bragg, L. & North, R.A. J. Neurosci. 33, 3557–3566 (2013).
Rokic, M.B. & Stojilkovic, S.S. Front. Cell. Neurosci. 7, 215 (2013).
Cao, E., Liao, M., Cheng, Y. & Julius, D. Nature 504, 113–118 (2013).
Baconguis, I., Bohlen, C.J., Goehring, A., Julius, D. & Gouaux, E. Cell 156, 717–729 (2014).
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Bean, B. Pore dilation reconsidered. Nat Neurosci 18, 1534–1535 (2015). https://doi.org/10.1038/nn.4148
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DOI: https://doi.org/10.1038/nn.4148
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