Nociceptors respond to both painful and itchy stimuli. MrgprA3-expressing neurons have now been found that are sparsely distributed in the skin and sense a wide variety of pruritogens.
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
Sensing acidosis: nociception or sngception?
Journal of Biomedical Science Open Access 29 November 2018
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Schmelz, M., Schmidt, R., Bickel, A., Handwerker, H.O. & Torebjörk, H.E. J. Neurosci. 17, 8003–8008 (1997).
Han, L. et al. Nat. Neurosci. 16, 174–182 (2013).
McCoy, E.S., Taylor-Blake, B. & Zylka, M.J. PLoS ONE 7, e36355 (2012).
Liu, Q. et al. J. Neurosci. 32, 14532–14537 (2012).
Namer, B. et al. J. Neurophysiol. 100, 2062206–2062209 (2008).
Ma, C., Nie, H., Gu, Q., Sikand, P. & Lamotte, R.H. J. Neurophysiol. 107, 357–363 (2012).
Shelley, W.B. & Arthur, R.P. Science 122, 469–470 (1955).
Reddy, V.B., Iuga, A.O., Shimada, S.G., LaMotte, R.H. & Lerner, E.A. J. Neurosci. 28, 4331–4335 (2008).
Sikand, P., Shimada, S.G., Green, B.G. & LaMotte, R.H. Pain 144, 66–75 (2009).
Koppert, W., Reeh, P.W. & Handwerker, H.O. Neurosci. Lett. 152, 117–120 (1993).
Koppert, W., Heyer, G. & Handwerker, H.O. Dermatology 192, 227–232 (1996).
Sun, Y.G. & Chen, Z.F. Nature 448, 700–703 (2007).
Davidson, S. et al. J. Neurosci. 27, 10007–10014 (2007).
Ross, S.E. et al. Neuron 65, 886–898 (2010).
Kremer, A.E. et al. Gastroenterology 139, 1008–1018 (2010).
Author information
Authors and Affiliations
Corresponding authors
Ethics declarations
Competing interests
The authors declare no competing financial interests.
Rights and permissions
About this article
Cite this article
Namer, B., Reeh, P. Scratching an itch. Nat Neurosci 16, 117–118 (2013). https://doi.org/10.1038/nn.3316
Published:
Issue Date:
DOI: https://doi.org/10.1038/nn.3316
This article is cited by
-
Neuropathischer Pruritus
Der Schmerz (2020)
-
Pruritus – ein weiter Weg von der Neurophysiologie zur Klinik
Der Hautarzt (2020)
-
The Complexity of Pruritus Requires a Variety of Treatment Strategies
Current Treatment Options in Allergy (2019)
-
Sensing acidosis: nociception or sngception?
Journal of Biomedical Science (2018)
-
Aktuelles zur Neurobiologie von Pruritus
Der Hautarzt (2018)