News and Views

Structural biology: Loading T4SS substrates

Structural analyses of the type IV coupling protein of the Dot/Icm type IV secretion system from Legionella pneumophila reveal how this platform recruits a plethora of substrates for translocation.

  • Subscribe to Nature Microbiology for full access:

    $59

    Subscribe

Additional access options:

Already a subscriber?  Log in  now or  Register  for online access.

References

  1. 1.

    & Microbiol. Mol. Biol. Rev. 73, 775–808 (2009).

  2. 2.

    & Nat. Rev. Microbiol. (2017).

  3. 3.

    et al. Nat. Microbiol. 2, 17114 (2017).

  4. 4.

    , , & Curr. Pharm. Des. 10, 1551–1565 (2004).

  5. 5.

    , , & PLoS Pathog. 8, e1002910 (2012).

  6. 6.

    , , & Mol. Microbiol. 55, 912–926 (2005).

  7. 7.

    & PLoS Pathog. 3, e188 (2007).

  8. 8.

    , , , & Mol. Microbiol. 95, 378–391 (2012).

  9. 9.

    & Mol. Microbiol. 6, 596–613 (2006).

  10. 10.

    et al. J. Bacteriol. 187, 2927–2938 (2005).

  11. 11.

    et al. J. Biol. Chem. 282, 25569–25576 (2007).

  12. 12.

    , , & J. Bacteriol. 195, 2691–2704 (2013).

  13. 13.

    et al. Nature 508, 550–553 (2014).

  14. 14.

    , , , & EMBO Rep. 18, 726–732 (2017).

  15. 15.

    & Annu. Rev. Biochem. 84, 603–629 (2015).

Download references

Author information

Affiliations

  1. Peter J. Christie is in the Department of Microbiology and Molecular Genetics, McGovern Medical School, 6431 Fannin Street, Houston, Texas 77030, USA.

    • Peter J. Christie

Authors

  1. Search for Peter J. Christie in:

Competing interests

The author declares no competing financial interests.

Corresponding author

Correspondence to Peter J. Christie.