Structural analyses of the type IV coupling protein of the Dot/Icm type IV secretion system from Legionella pneumophila reveal how this platform recruits a plethora of substrates for translocation.
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References
Alvarez-Martinez, C. E. & Christie, P. J. Microbiol. Mol. Biol. Rev. 73, 775–808 (2009).
Qiu, J. & Luo, Z. Q. Nat. Rev. Microbiol. http://doi.org/gbnh9t (2017).
Kwak, M.-J. et al. Nat. Microbiol. 2, 17114 (2017).
Gomis-Rüth, F. X., Solà, M., de la Cruz, F. & Coll, M. Curr. Pharm. Des. 10, 1551–1565 (2004).
Sutherland, M. C., Nguyen, T. L., Tseng, V. & Vogel, J. P. PLoS Pathog. 8, e1002910 (2012).
Ninio, S., Zuckman-Cholon, D. M., Cambronne, E. D. & Roy, C. R. Mol. Microbiol. 55, 912–926 (2005).
Cambronne, E. D. & Roy, C. R. PLoS Pathog. 3, e188 (2007).
Vincent, C. D., Friedman, J. R., Jeong, K. C., Sutherland, M. C. & Vogel, J. P. Mol. Microbiol. 95, 378–391 (2012).
Vincent, C. D. & Vogel, J. P. Mol. Microbiol. 6, 596–613 (2006).
Buscher, B. A. et al. J. Bacteriol. 187, 2927–2938 (2005).
Tato, I. et al. J. Biol. Chem. 282, 25569–25576 (2007).
Cascales, E., Atmakuri, K., Sarkar, M. K. & Christie, P. J. J. Bacteriol. 195, 2691–2704 (2013).
Low, H. H. et al. Nature 508, 550–553 (2014).
Ghosal, D., Chang, Y. W., Jeong, K. C., Vogel, J. P. & Jensen, G. J. EMBO Rep. 18, 726–732 (2017).
Chandran Darbari, V. & Waksman, G. Annu. Rev. Biochem. 84, 603–629 (2015).
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Christie, P. Structural biology: Loading T4SS substrates. Nat Microbiol 2, 17125 (2017). https://doi.org/10.1038/nmicrobiol.2017.125
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DOI: https://doi.org/10.1038/nmicrobiol.2017.125