Modeling cell-cycle state from the transcriptional profiles of single cells can improve the ability to group cells by function.
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References
Buettner, F. et al. Computational analysis of cell-to-cell heterogeneity in single-cell RNA-sequencing data reveals hidden subpopulations of cells. Nat. Biotechnol. 33, 155–160 (2015).
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Nawy, T. Kindred cells among the crowd. Nat Methods 12, 170–171 (2015). https://doi.org/10.1038/nmeth.3307
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DOI: https://doi.org/10.1038/nmeth.3307