Deletion of a genomic locus may affect the function of neighboring loci, creating genetic uncertainty. Researchers now present a computational algorithm for identifying such neighboring-gene effects and improving the quality of functional annotations.
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References
Giaever, G. et al. Nature 418, 387–391 (2002).
Botstein, D. & Fink, G.R. Genetics 189, 695–704 (2011).
Ben-Shitrit, T. et al. Nat. Methods 9, 373–378 (2012).
Brown, T.A. Genomes 2nd edn. (Wiley-Liss, 2002).
Costanzo, M. et al. Science 327, 425–431 (2010).
Keyes, B.E. & Burke, D.J. Curr. Biol. 19, 472–478 (2009).
Cohen, B.A., Mitra, R.D., Hughes, J.D. & Church, G.M. Nat. Genet. 26, 183–186 (2000).
Pal, C. & Hurst, L.D. Nat. Genet. 33, 392–395 (2003).
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Baryshnikova, A., Andrews, B. Neighboring-gene effect: a genetic uncertainty principle. Nat Methods 9, 341–343 (2012). https://doi.org/10.1038/nmeth.1936
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DOI: https://doi.org/10.1038/nmeth.1936