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Keep the 'phospho' on MAPK, be happy

Nature Medicine volume 16, pages 1187–1188 (2010)Cite this article

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Depression ruins the lives of millions of people, causing dysphoria and anguish. New findings in rodents and human brain shed light on the mechanisms of this disease, uncovering a phosphatase as a new target to treat depressive behaviors (pages 1328–1332).

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Figure 1: The serine-threonine phosphatase MKP-1 is a key control point in the neurobiology of depression.

Marina Corral

References

  1. Moussavi, S. et al. Lancet 370, 851–858 (2007).

    Article  Google Scholar 

  2. Price, J.L. & Drevets, W.C. Neuropsychopharmacology 35, 192–216 (2010).

    Article  Google Scholar 

  3. Berton, O. & Nestler, E.J. Nat. Rev. Neurosci. 7, 137–151 (2006).

    Article  CAS  Google Scholar 

  4. Duric, V. et al. Nat. Med. 16, 1328–1332 (2010).

    Article  CAS  Google Scholar 

  5. Keyse, S.M. & Emslie, E.A. Nature 359, 644–647 (1992).

    Article  CAS  Google Scholar 

  6. Sun, H. et al. Cell 75, 487–493 (1993).

    Article  CAS  Google Scholar 

  7. Morrison, D.K. & Davis, R.J. Annu. Rev. Cell Dev. Biol. 19, 91–118 (2003).

    Article  CAS  Google Scholar 

  8. Jeffrey, K.L. et al. Nat. Rev. Drug Discov. 6, 391–403 (2007).

    Article  CAS  Google Scholar 

  9. Li, H., Zhang, L. & Huang, Q. Behav. Brain Res. 205, 32–37 (2009).

    Article  CAS  Google Scholar 

  10. Breitwieser, W. et al. Genes Dev. 21, 2069–2082 (2007).

    Article  CAS  Google Scholar 

  11. Czéh, B. et al. Neuropsychopharmacology 31, 1616–1626 (2006).

    Article  Google Scholar 

  12. Wu, J.J. et al. Cell Metab. 4, 61–73 (2006).

    Article  CAS  Google Scholar 

  13. Carlson, J. et al. Am. J. Pathol. 175, 1564–1573 (2009).

    Article  CAS  Google Scholar 

  14. Cizza, G., Primma, S. & Csako, G. Trends Endocrinol. Metab. 20, 367–373 (2009).

    Article  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Schahram Akbarian is in the Department of Psychiatry, Brudnick Neuropsychiatric Research Institute, University of Massachusetts Medical School, Worcester, Massachusetts, USA,

    Schahram Akbarian

  2. Roger J. Davis is in the Program in Molecular Medicine, Howard Hughes Medical Institute, University of Massachusetts Medical School, Worcester, Massachusetts, USA.,

    Roger J Davis

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  1. Schahram Akbarian
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  2. Roger J Davis
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Correspondence to Schahram Akbarian or Roger J Davis.

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Akbarian, S., Davis, R. Keep the 'phospho' on MAPK, be happy. Nat Med 16, 1187–1188 (2010). https://doi.org/10.1038/nm1110-1187

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