Although hematological cancers are genomically unstable, the mechanisms by which they evade DNA damage–induced cell death are largely unknown. A current study has revealed that the Hippo signaling pathway transcriptional regulator YAP1 activates an ABL1/p73-mediated proapoptotic effect in response to DNA damage, suggesting that YAP1 has a tumor suppressor function and that the Hippo pathway is a potential therapeutic target in human cancers.
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References
Halazonetis, T.D., Gorgoulis, V.G. & Bartek, J. Science 319, 1352–1355 (2008).
Levy, D., Adamovich, Y., Reuven, N. & Shaul, Y. Cell Death Differ. 14, 743–751 (2007).
Cottini, F. et al. Nat. Med. 20, 599–606 (2014).
Zhou, D. et al. Cancer Cell 16, 425–438 (2009).
Liu, A.M., Wong, K.F., Jiang, X., Qiao, Y. & Luk, J.M. Biochim. Biophys. Acta 1826, 357–364 (2012).
Harvey, K.F., Zhang, X. & Thomas, D.M. Nat. Rev. Cancer 13, 246–257 (2013).
Zhao, B. et al. Genes Dev. 22, 1962–1971 (2008).
Yu, F.X. & Guan, K.L. Genes Dev. 27, 355–371 (2013).
Zhao, B., Tumaneng, K. & Guan, K.L. Nat. Cell Biol. 13, 877–883 (2011).
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Luk, J., Guan, KL. An alternative DNA damage pathway to apoptosis in hematological cancers. Nat Med 20, 587–588 (2014). https://doi.org/10.1038/nm.3593
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DOI: https://doi.org/10.1038/nm.3593