A new study demonstrates involvement of the inhibitory receptor CTLA-4 in T cell exhaustion during infection with human immunodeficiency virus, adding complexity and diversity to the inhibitory pathways regulating T cell responses during chronic viral infections in humans.
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References
Kaufmann, D.E. et al. Nat. Immunol. 8, 1246–1254 (2007).
Blackburn, S.D. & Wherry, E.J. Trends Microbiol. 15, 143–146 (2007).
Greenwald, R.J., Freeman, G.J. & Sharpe, A.H. Annu. Rev. Immunol. 23, 515–548 (2005).
Barber, D.L. et al. Nature 439, 682–687 (2006).
Day, C.L. et al. Nature 443, 350–354 (2006).
Petrovas, C. et al. J. Exp. Med. 203, 2281–2292 (2006).
Trautmann, L. et al. Nat. Med. 12, 1198–1202 (2006).
Steiner, K. et al. Clin. Exp. Immunol. 115, 451–457 (1999).
D'Souza, M. et al. J. Immunol. 179, 1979–1987 (2007).
Korman, A.J., Peggs, K.S. & Allison, J.P. Adv. Immunol. 90, 297–339 (2006).
Hryniewicz, A. et al. Blood 108, 3834–3842 (2006).
Butte, M.J. et al. Immunity 27, 111–122 (2007).
Murphy, K.M., Nelson, C.A. & Sedy, J.R. Nat. Rev. Immunol. 6, 671–681 (2006).
Parry, R.V. et al. Mol. Cell. Biol. 25, 9543–9553 (2005).
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Crawford, A., Wherry, E. Inhibitory receptors: whose side are they on?. Nat Immunol 8, 1201–1203 (2007). https://doi.org/10.1038/ni1107-1201
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DOI: https://doi.org/10.1038/ni1107-1201
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