The importance of cross-priming in vivo is controversial because its relative contribution in the presence of conventional priming is unclear. However, data from the examination of a conserved tyrosine residue in the cytoplasmic tail of MHC class I favor the cross-priming hypothesis.
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Amigorena, S. Y in X priming. Nat Immunol 4, 1047–1048 (2003). https://doi.org/10.1038/ni1103-1047
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DOI: https://doi.org/10.1038/ni1103-1047
