Tissue-specific antigens are expressed in the thymic medulla under the influence of the AIRE gene, suggesting that unresponsiveness to these peripheral antigens is a result of central tolerance. New data on T cell tolerance in AIRE−/− mice strongly support this hypothsis.
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
Delayed functional maturation of natural regulatory T cells in the medulla of postnatal thymus: role of TSLP
BMC Immunology Open Access 03 April 2006
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on SpringerLink
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Stockinger, B. Adv. Immunol. 71, 229–265 (1999).
Kyewski, B., Derbinski, J., Gotter, J. & Klein, L. Trends Immunol. 23, 364–371 (2002).
Sprent, J. & Kishimoto, H. Immunol. Rev. 185, 126–135 (2002).
Bjorses, P. et al. Am. J. Hum. Genet. 66, 378–392 (2000).
Ramsey, C. et al. Hum Mol Genet. 11, 397–409 (2002).
Anderson, M.S. et al. Science 298, 1395–1401 (2002).
Liston, P., Lesage, S., Wilson, J., Peltonen, L. & Goodnow, C.C. Nat. Immunol. 4, 350–354 (2003).
Heath, W.R., Karamalis, F., Donoghue, J. & Miller, J.F. J. Immunol. 155, 2339–2349 (1995).
Surh, C.D. & Sprent, J. Microbes Infect. 4, 51–56 (2002).
Jordan, M.S. et al. Nat. Immunol. 2, 301–306 (2001).
Sprent, J., Kosaka, H., Gao, E.K., Surh, C.D. & Webb, S.R. Immunol. Rev. 133, 151–176 (1993).
Hammerling, G.J., Schonrich, G., Ferber, I. & Arnold, B. Immunol. Rev. 133, 93–104 (1993).
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Sprent, J., Surh, C. Knowing one's self: central tolerance revisited. Nat Immunol 4, 303–304 (2003). https://doi.org/10.1038/ni0403-303
Issue Date:
DOI: https://doi.org/10.1038/ni0403-303
This article is cited by
-
An evaluation of the clinical significance of FOXP3+ infiltrating cells in human breast cancer
Breast Cancer Research and Treatment (2011)
-
Delayed functional maturation of natural regulatory T cells in the medulla of postnatal thymus: role of TSLP
BMC Immunology (2006)
-
Transplant tolerance: models, concepts and facts
Journal of Molecular Medicine (2006)
-
Peripheral antigen-expressing cells in type 1 diabetes
Current Diabetes Reports (2004)