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Uhrf to Treg cells: reinforcing the mucosal peacekeepers

Nature Immunology volume 15, pages 533–534 (2014)Cite this article

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The colonization of the colon with commensal microflora drives the induction and population expansion of regulatory T cells, an immunological adaption needed to prevent mucosal inflammation. The epigenetic modifier Uhrf1 acts as a key molecular mediator of such expansion and the establishment of a harmonious mucosal environment.

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Figure 1: Interactions between gut microbiota and colonic Treg cells.

Katie Vicari/Nature Publishing Group

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Authors and Affiliations

  1. and the Department of Medical Biology, Daniel H.D. Gray is with The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia, University of Melbourne, Melbourne, Australia.,

    Daniel H D Gray

  2. and the Department of Microbiology and Immunology, Adrian Liston is with the Autoimmune Genetics Laboratory, VIB, Leuven, Belgium, University of Leuven, Leuven, Belgium.,

    Adrian Liston

Authors
  1. Daniel H D Gray
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  2. Adrian Liston
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Correspondence to Daniel H D Gray or Adrian Liston.

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The authors declare no competing financial interests.

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Gray, D., Liston, A. Uhrf to Treg cells: reinforcing the mucosal peacekeepers. Nat Immunol 15, 533–534 (2014). https://doi.org/10.1038/ni.2893

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