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Nonclassical NK cell education

Diseased host cells are eliminated more effectively when natural killer cells grow up in the presence of classical major histocompatibility complex (MHC) class I molecules. The nonclassical MHC class I molecule H2-M3 can exert an analogous effect.

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Figure 1: Variability in the responsiveness of Ly49A+ NK cells.

Debbie Maizels

References

  1. Andrews, D.M. et al. Nat. Immunol. 13, 1171–1177 (2012).

    Article  CAS  Google Scholar 

  2. Karlhofer, F.M., Ribaudo, R.K. & Yokoyama, W.M. Nature 358, 66–70 (1992).

    Article  CAS  Google Scholar 

  3. Kim, S. et al. Nature 436, 709–713 (2005).

    Article  CAS  Google Scholar 

  4. Doucey, M.A. et al. Nat. Immunol. 5, 328–336 (2004).

    Article  CAS  Google Scholar 

  5. Chalifour, A. et al. Immunity 30, 337–347 (2009).

    Article  CAS  Google Scholar 

  6. Joncker, N.T., Shifrin, N., Delebecque, F. & Raulet, D.H. J. Exp. Med. 207, 2065–2082 (2010).

    Article  CAS  Google Scholar 

  7. Chiu, N.M., Chun, T., Fay, M., Mandal, M. & Wang, C.R. J. Exp. Med. 190, 423–434 (1999).

    Article  CAS  Google Scholar 

  8. Lakshmikanth, T. et al. J. Clin. Invest. 119, 1251–1263 (2009).

    Article  CAS  Google Scholar 

  9. Xu, H., Chun, T., Choi, H.J., Wang, B. & Wang, C.R. J. Exp. Med. 203, 449–459 (2006).

    Article  Google Scholar 

  10. Anfossi, N. et al. J. Immunol. 173, 3773–3782 (2004).

    Article  CAS  Google Scholar 

Download references

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Correspondence to Werner Held.

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Held, W. Nonclassical NK cell education. Nat Immunol 13, 1135–1137 (2012). https://doi.org/10.1038/ni.2470

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