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The Foxp3 interactome: a network perspective of Treg cells

Foxp3 protein complexes orchestrate the transcriptional network of regulatory T cells. The Foxp3 interactome is now identified and may act as a genetic switch that controls the differentiation of regulatory T cells.

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Figure 1: A hypothetical transcriptional circuitry that establishes the Treg cell signature.

Debbie Maizels

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Correspondence to Shohei Hori.

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Hori, S. The Foxp3 interactome: a network perspective of Treg cells. Nat Immunol 13, 943–945 (2012). https://doi.org/10.1038/ni.2424

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