'Elite controllers' of human immunodeficiency virus (HIV) maintain a long-term disease-free status after infection with HIV. A comparison of elite controllers and people who progress to disease after infection with HIV now suggests that clonotypic profiles of HIV-specific CD8+ T cells may underlie elite control.
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References
Moir, S., Chun, T.W. & Fauci, A.S. Annu. Rev. Pathol. 6, 223–248 (2011).
Deeks, S.G. & Walker, B.D. Immunity 27, 406–416 (2007).
Goulder, P.J.R. & Watkins, D.I. Nat. Rev. Immunol. 8, 619–630 (2008).
The International HIV Controllers Study Science 330, 1551–1557 (2010).
Chen, H. et al. Nat. Immunol. 13, 691–700 (2012).
Hersperger, A.R., Migueles, S.A., Betts, M.R. & Connors, M. Curr. Opin. HIV AIDS 6, 169–173 (2011).
Virgin, H.W., Wherry, E.J. & Ahmed, R. Cell 138, 30–50 (2009).
Kosmrlj, A. Nature 465, 350–354 (2010).
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M.B.F. is an employee of Merck.
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Feinberg, M., Ahmed, R. Born this way? Understanding the immunological basis of effective HIV control. Nat Immunol 13, 632–634 (2012). https://doi.org/10.1038/ni.2351
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DOI: https://doi.org/10.1038/ni.2351