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Fusion of the nucleoporin gene NUP98 to HOXA9 by the chromosome translocation t(7;11)(p15;p15) in human myeloid leukaemia

Nature Genetics volume 12, pages 154–158 (1996)Cite this article

Abstract

Expression of HoxaT and Hoxa9 is activated by proviral integration in BXH2 murine myeloid leukaemias. This result, combined with the mapping of the HOXA locus to human chromosome 7p15, suggested that one of the HOXA genes might be involved in the t(7;11)(p15;p15) translocation found in some human myeloid leukaemia patients. Here we show that in three patients with t(7;11), the chromosome rearrangement creates a genomic fusion between the HOXA9 gene and the nucleoporin gene NUP98 on chromosome 11 p15. The translocation produces an invariant chimaeric NUP98/HOXA9 transcript containing the amino terminal half of NUP98 fused in frame to HOXA9. These studies identify HOXA9 as an important human myeloid leukaemia gene and suggest an important role for nucleoporins in human myeloid leukaemia given that a second nucleoporin, NUP214, has also been implicated in human myeloid leukaemia.

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Authors and Affiliations

  1. Mammalian Genetics Laboratory, ABL-Basic Research Program, NCI-Frederick Cancer Research and Development Center, Frederick, Maryland, 21702

    Takuro Nakamura, David A. Largaespada, Nancy A. Jenkins, Neal G. Copeland & John D. Shaughnessy Jr.

  2. Departments of Medicine, Oncology, and Molecular Biology, Johns Hopkins University School of Medicine, Baltimore, Maryland, 21205, USA

    Maxwell P. Lee, Laura A. Johnson & Andrew P Feinberg

  3. First Department of Internal Medicine, Tokyo Medical College, Tokyo, Japan

    Kazuma Ohyashiki & Keisuke Toyama

  4. Institute of Hematobgy, Rui-Jin Hospital, Shanghai Second Medical University, Shanghai, China

    Sai Juan Chen

  5. Department of Cell Biology, University of New Mexico Cancer Center, Albuquerque, New Mexico, 87131, USA

    Cheryl L. Willman & I-Ming Chen

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  1. Takuro Nakamura
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Nakamura, T., Largaespada, D., Lee, M. et al. Fusion of the nucleoporin gene NUP98 to HOXA9 by the chromosome translocation t(7;11)(p15;p15) in human myeloid leukaemia. Nat Genet 12, 154–158 (1996). https://doi.org/10.1038/ng0296-154

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  • DOI: https://doi.org/10.1038/ng0296-154

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