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Divergent evolutionary trajectories in transplanted tumor models

Human-derived tumor models are becoming popular in the context of personalized medicine, but a new study shows that these models could be less representative of primary tumors than previously thought, particularly when using late passages.

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Author information

Affiliations

  1. Carlos Villacorta-Martin, Amanda J. Craig and Augusto Villanueva are in the Liver Cancer Research Program, Division of Liver Diseases, Tisch Cancer Institute, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.

    • Carlos Villacorta-Martin
    • , Amanda J Craig
    •  & Augusto Villanueva
  2. Augusto Villanueva is also in the Division of Hematology and Medical Oncology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.

    • Augusto Villanueva

Authors

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Competing interests

A.V. receives research support from Champions Oncology.

Corresponding author

Correspondence to Augusto Villanueva.