Regulation of epigenetic factors through their recruitment to specific genomic regions is still poorly understood. A recent study demonstrates a global mechanism of tethering Polycomb group (PcG) proteins through sequence-specific DNA-binding factors.
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March, E., Farrona, S. Polycomb silencing mediated by specific DNA-binding recruiters. Nat Genet 49, 1416–1417 (2017). https://doi.org/10.1038/ng.3961
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DOI: https://doi.org/10.1038/ng.3961