Comparative genomic analyses of primary tumors and metastases within individuals with pancreatic cancer have exposed the complex clonal dynamics that underlie the dissemination of cancer cells to distant sites. Recent studies implicate non-genetic mechanisms in this process, particularly fluctuations in chromatin states and metabolism, which can endow rare cells within a primary tumor with metastatic potential.
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
Pancreatic cancers suppress negative feedback of glucose transport to reprogram chromatin for metastasis
Nature Communications Open Access 13 August 2020
-
Integrated epigenetic biomarkers in circulating cell-free DNA as a robust classifier for pancreatic cancer
Clinical Epigenetics Open Access 23 July 2020
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Garraway, L.A. & Lander, E.S. Cell 153, 17–37 (2013).
Stratton, M.R., Campbell, P.J. & Futreal, P.A. Nature 458, 719–724 (2009).
Gibson, W.J. et al. Nat. Genet. 48, 848–855 (2016).
Sanborn, J.Z. et al. Proc. Natl. Acad. Sci. USA 112, 10995–11000 (2015).
Gundem, G. et al. Nature 520, 353–357 (2015).
Campbell, P.J. et al. Nature 467, 1109–1113 (2010).
Yachida, S. et al. Nature 467, 1114–1117 (2010).
Vanharanta, S. & Massagué, J. Cancer Cell 24, 410–421 (2013).
McDonald, O.G. et al. Nat. Genet. 49, 358–366 (2017).
Makohon-Moore, A.P. et al. Nat. Genet. 49, 367–376 (2017).
Tam, W.L. & Weinberg, R.A. Nat. Med. 19, 1438–1449 (2013).
Denny, S.K. et al. Cell 166, 328–342 (2016).
Feinberg, A.P., Ohlsson, R. & Henikoff, S. Nat. Rev. Genet. 7, 21–33 (2006).
Author information
Authors and Affiliations
Corresponding authors
Ethics declarations
Competing interests
The authors declare no competing financial interests.
Rights and permissions
About this article
Cite this article
Vakoc, C., Tuveson, D. Untangling the genetics from the epigenetics in pancreatic cancer metastasis. Nat Genet 49, 323–324 (2017). https://doi.org/10.1038/ng.3798
Published:
Issue Date:
DOI: https://doi.org/10.1038/ng.3798
This article is cited by
-
Integrated epigenetic biomarkers in circulating cell-free DNA as a robust classifier for pancreatic cancer
Clinical Epigenetics (2020)
-
Pancreatic cancers suppress negative feedback of glucose transport to reprogram chromatin for metastasis
Nature Communications (2020)