Recent molecular classification of colorectal cancer (CRC) has identified a poor-prognosis transcriptional subtype associated with mesenchymal traits. New studies used CRC transcriptomic data to show that tumor-associated stroma mimics the gene signature of epithelial-to-mesenchymal transition (EMT) and found no evidence for EMT of colorectal tumor cells.
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References
De Sousa E Melo, F. et al. Nat. Med. 19, 614–618 (2013).
Sadanandam, A. et al. Nat. Med. 19, 619–625 (2013).
Marisa, L. et al. PLoS Med. 10, e1001453 (2013).
Kalluri, R. & Weinberg, R.A. J. Clin. Invest. 119, 1420–1428 (2009).
Isella, C. et al. Nat. Genet. 47, 312–319 (2015).
Calon, A. et al. Nat. Genet. 47, 320–329 (2015).
Yoshihara, K. et al. Nat. Commun. 4, 2612 (2013).
Martínez, E. et al. Oncogene doi:10.1038/onc.2014.216 (4 August 2014).
Cheng, W.Y., Ou Yang, T.H. & Anastassiou, D. PLoS Comput. Biol. 9, e1002920 (2013).
Busuttil, R.A. et al. Clin. Cancer Res. 20, 2761–2772 (2014).
Hanahan, D. & Weinberg, R.A. Cell 144, 646–674 (2011).
Thiery, J.P., Acloque, H., Huang, R.Y. & Nieto, M.A. Cell 139, 871–890 (2009).
Loeffler, M., Kruger, J.A., Niethammer, A.G. & Reisfeld, R.A. J. Clin. Invest. 116, 1955–1962 (2006).
Pyonteck, S.M. et al. Nat. Med. 19, 1264–1272 (2013).
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Kim, H., Verhaak, R. Transcriptional mimicry by tumor-associated stroma. Nat Genet 47, 307–309 (2015). https://doi.org/10.1038/ng.3255
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DOI: https://doi.org/10.1038/ng.3255
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