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Risk of serious bacterial infection: treatment with anti-TNF versus methotrexate

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References

  1. Thomas E et al. (2003) National study of cause-specific mortality in rheumatoid arthritis, juvenile chronic arthritis, and other rheumatic conditions: a 20 year followup study. J Rheumatol 30: 958–965

    PubMed  Google Scholar 

  2. Bongartz T et al. (2006) Anti-TNF antibody therapy in rheumatoid arthritis and the risk of serious infections and malignancies: systematic review and meta-analysis of rare harmful effects in randomized controlled trials. JAMA 295: 2275–2285

    Article  CAS  Google Scholar 

  3. Listing J et al. (2005) Infections in patients with rheumatoid arthritis treated with biologic agents. Arthritis Rheum 52: 3403–3412

    Article  CAS  Google Scholar 

  4. Dixon WG et al. (2006) Rates of serious infection, including site-specific and bacterial intracellular infection, in rheumatoid arthritis patients receiving anti-tumor necrosis factor therapy: results from the British Society for Rheumatology Biologics Register. Arthritis Rheum 54: 2368–2376

    Article  CAS  Google Scholar 

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Acknowledgements

The synopsis was written by Jasmine Farsarakis, Associate Editor, Nature Clinical Practice.

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Correspondence to Angela Zink.

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Zink, A., Listing, J. Risk of serious bacterial infection: treatment with anti-TNF versus methotrexate. Nat Rev Rheumatol 3, 546–547 (2007). https://doi.org/10.1038/ncprheum0594

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