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References
Dieppe P et al. (1993) Prediction of the progression of joint space narrowing in osteoarthritis of the knee by bone scintigraphy. Ann Rheum Dis 52: 557–563
Mansell JP and Bailey AJ (1998) Abnormal cancellous bone collagen metabolism in osteoarthritis. J Clin Invest 101: 1596–1603
Knott L and Bailey AJ (1998) Collagen cross-links in mineralizing tissues: a review of their chemistry, function and clinical relevance. Bone 22: 181–187
Bailey AJ et al. (2002) Phenotypic expression of osteoblast collagen in osteoarthritic bone: production of type I homotrimer. Int J Biochem Cell Biol 34: 176–182
Hilal G et al. (1998) Osteoblast-like cells from human subchondral osteoarthritic bone demonstrate an altered phenotype in vitro: possible role in subchondral bone sclerosis. Arthritis Rheum 41: 891–899
Burr D (2004) The importance of subchondral bone in the progression of osteoarthritis. J Rheumatol Suppl 70: 77–80
Anderson-MacKenzie JM et al. (2005) Fundamental subchondral bone changes in spontaneous knee osteoarthritis. Int J Biochem Cell Biol 37: 224–236
Quasnichka HL et al. (2005) Cruciate ligament laxity and femoral intercondylar notch narrowing in early-stage knee osteoarthritis. Arthritis Rheum 52: 3100–3109
Westacott CM et al. (1997) Alteration of cartilage metabolism by cells from osteoarthritic bone. Arthritis Rheum 40: 1282–1291
Westacott CM (2002) Interactions between subchondral bone and cartilage in OA. Cells from osteoarthritic bone can alter cartilage metabolism. J Musculoskelet Neuronal Interact 2: 507–509
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Mansell, J., Collins, C. & Bailey, A. Bone, not cartilage, should be the major focus in osteoarthritis. Nat Rev Rheumatol 3, 306–307 (2007). https://doi.org/10.1038/ncprheum0505
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DOI: https://doi.org/10.1038/ncprheum0505
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