Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Practice Point
  • Published:

Re-examining aggressive anticoagulant therapy: the case of acute coronary syndromes

Nature Clinical Practice Cardiovascular Medicine volume 5, pages 72–73 (2008)Cite this article

boxed-textAllen LaPointe NM et al. (2007) Enoxaparin dosing and associated risk of in-hospital bleeding and death in patients with non ST-segment elevation acute coronary syndromes. Arch Intern Med 167: 1539–1544

Background

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

References

  1. Moscucci M et al. (2003) Predictors of major bleeding in acute coronary syndromes: the Global Registry of Acute Coronary Events (GRACE). Eur Heart J 24: 1815–1823

    Article  CAS  Google Scholar 

  2. Fox KA et al. for the OASIS-5 Investigators (2007) Influence of renal function on the efficacy and safety of fondaparinux relative to enoxaparin in non ST-segment elevation acute coronary syndromes. Ann Intern Med 147: 304–310

    Article  Google Scholar 

  3. Eikelboom JW et al. (2006) Adverse impact of bleeding on prognosis in patients with acute coronary syndromes. Circulation 114: 774–782

    Article  Google Scholar 

  4. Yusuf S et al. for the OASIS-6 Trial Group (2006) Effects of fondaparinux on mortality and reinfarction in patients with acute ST-segment elevation myocardial infarction: the OASIS-6 randomized trial. JAMA 295: 1519–1530

    Article  CAS  Google Scholar 

  5. Rao SV et al. (2005) Impact of bleeding severity on clinical outcomes among patients with acute coronary syndromes. Am J Cardiol 96: 1200–1206

    Article  Google Scholar 

Download references

Acknowledgements

The synopsis was written by Alexandra King, Associate Editor, Nature Clinical Practice.

Author information

Authors and Affiliations

  1. M Crowther is Chair of the Division of Hematology and a Professor in the Department of Medicine at McMaster University, and W Lim is an Assistant Professor in the Department of Medicine at McMaster University, Head of the Hematology Service at St Joseph's Hospital, and Senior Clinical Research Advisor for the Father Sean O'Sullivan Research Center at St Joseph's Healthcare, Hamilton, ON, Canada.,

    Mark Crowther & Wendy Lim

Authors
  1. Mark Crowther
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Wendy Lim
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Mark Crowther.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Crowther, M., Lim, W. Re-examining aggressive anticoagulant therapy: the case of acute coronary syndromes. Nat Rev Cardiol 5, 72–73 (2008). https://doi.org/10.1038/ncpcardio1059

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/ncpcardio1059

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing