Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Practice Point
  • Published:

Does eplerenone benefit postinfarction patients with heart failure and left ventricular systolic dysfunction?

Nature Clinical Practice Cardiovascular Medicine volume 2, pages 618–619 (2005)Cite this article

boxed-textPitt B et al. for the EPHESUS Investigators (2005) Eplerenone reduces mortality 30 days after randomization following acute myocardial infarction in patients with left ventricular systolic dysfunction and heart failure. J Am Coll Cardiol 46: 425–431

Eplerenone should be given to patients with LVSD and HF after MI, before hospital discharge, with careful monitoring of renal function and potassium levels

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

References

  1. Antman et al. (2004) ACC/AHA Guidelines for the management of patients with ST-elevation myocardial infarction-executive summary: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. J Am Coll Cardiol 44: 671–719

    Article  Google Scholar 

  2. Velazquez EJ et al. for the VALIANT registry (2004) An international perspective on heart failure and left ventricular systolic dysfunction complicating myocardial infarction: the VALIANT registry. Eur Heart J 25: 1911–1919

    Article  Google Scholar 

  3. Flather MD et al. (2000) Long term ACE-inhibitor therapy in patients with heart failure or left ventricular dysfunction: a systematic overview of data from individual patients. Lancet 355: 1575–1581

    Article  CAS  Google Scholar 

  4. Pfeffer MA et al. (2003) Valsartan, captopril or both in myocardial infarction complicated by heart failure, left ventricular dysfunction or both. N Engl J Med 349: 1843–1906

    Article  Google Scholar 

  5. Pitt B et al. (2003) Eplerenone, a selective aldosterone blocker, in patients with left ventricular dysfunction after myocardial infarction. N Engl J Med 348: 1309–1321

    Article  CAS  Google Scholar 

  6. Juurlink DN et al. (2004) Rates of hyperkalemia after publication of the Randomized Aldactone Evaluation Study. N Engl J Med 351: 543–551

    Article  CAS  Google Scholar 

Download references

Acknowledgements

The synopsis was written by Hannah Camm, Associate Editor, Nature Clinical Practice.

Author information

Authors and Affiliations

  1. Director of the Research Center of the Italian Association of Hospital Cardiologists (ANMCO), Florence, Italy

    Aldo Pietro Maggioni

Authors
  1. Aldo Pietro Maggioni
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Aldo Pietro Maggioni.

Ethics declarations

Competing interests

The author declares no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Maggioni, A. Does eplerenone benefit postinfarction patients with heart failure and left ventricular systolic dysfunction?. Nat Rev Cardiol 2, 618–619 (2005). https://doi.org/10.1038/ncpcardio0379

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1038/ncpcardio0379

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing