Conformational transitions triggered by the binding of neurotransmitters open the gate of the ion channel domain of glutamate receptors, regulating the transmission of information through the nervous system. Using single-molecule fluorescence resonance energy transfer (smFRET), the agonist-binding domain of the GluA2 receptor, isolated in solution, is observed to interconvert among distinct large-scale conformational states.
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References
Traynelis, S.F. et al. Pharmacol. Rev. 62, 405–496 (2010).
Landes, C.F., Rambhadran, A., Taylor, J.N., Salatan, F. & Jayaraman, V. Nat. Chem. Biol. 7, 168–173 (2011).
Ramanoudjame, G., Du, M., Mankiewicz, K.A. & Jayaraman, V. Proc. Natl. Acad. Sci. USA 103, 10473–10478 (2006).
Lau, A.Y. & Roux, B. Structure 15, 1203–1214 (2007).
Lau, A.Y. & Roux, B. Nat. Struct. Mol. Biol. published online, 10.1038/nsmb.2010 (13 February 2011).
McFeeters, R.L. & Oswald, R.E. Biochemistry 41, 10472–10481 (2002).
Valentine, E.R. & Palmer, A.G. III. Biochemistry 44, 3410–3417 (2005).
Ahmed, A.H., Loh, A.P., Jane, D.E. & Oswald, R.E. J. Biol. Chem. 282, 12773–12784 (2007).
Fenwick, M.K. & Oswald, R.E. J. Biol. Chem. 285, 12334–12343 (2010).
Robert, A., Armstrong, N., Gouaux, J.E. & Howe, J.R. J. Neurosci. 25, 3752–3762 (2005).
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Lau, A., Roux, B. One domain, multiple conformations. Nat Chem Biol 7, 130–131 (2011). https://doi.org/10.1038/nchembio.527
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DOI: https://doi.org/10.1038/nchembio.527
