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Biosynthesis

A new (old) way of hijacking tRNA

Nature Chemical Biology volume 6, pages 795–796 (2010)Cite this article

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Aminoacylation of tRNA is the cellular process for providing aminoacyl donors for the ribosome synthesis of polypeptides. New research highlights an unexpected structural overlap between enzymes involved in this process and those involved in the biosynthesis of cyclodipeptides, an important class of bioactive molecules.

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Figure 1: Rv2275 steals aminoacyl-tRNAs via a synthetase structure.

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  1. Georges Lahoud and Ya-Ming Hou are in the Department of Biochemistry and Molecular Biology at Thomas Jefferson University, Philadelphia, Pennsylvania, USA.,

    Georges Lahoud & Ya-Ming Hou

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  1. Georges Lahoud
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  2. Ya-Ming Hou
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Correspondence to Ya-Ming Hou.

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The authors declare no competing financial interests.

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Lahoud, G., Hou, YM. A new (old) way of hijacking tRNA. Nat Chem Biol 6, 795–796 (2010). https://doi.org/10.1038/nchembio.459

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